Select File > Settings and choose NONMEM in the left list.
Enable nmfe runs — When checked, allows use of nmfe for NONMEM executions.
Run before NONMEM (nmfe) execution — Commands to execute prior to the NONMEM run.
Run after NONMEM (nmfe) execution — Commands to execute after the NONMEM run.
Central parafiles location — Folder where parallelization files are stored.
Set the number of nodes... — When checked, determines the number of nodes by looking at the NODES environment variable setting.