Simcyp VBE has the following system requirements:
Windows 10
Simcyp Simulator v23 installation and license
R 4.3.2 or higher
Prior to using Simcyp VBE in Pirana, there are some installation and verification steps that need to be completed.
Install Simcyp Simulator v23
Contact simcyp.support@certara.com to request Simcyp Simulator.
Install Simcyp R package and dependencies
The Simcyp R package requires additional package dependencies, which can first be installed from CRAN using the following command:
install.packages(c("Rcpp", "XML", "xml2", "RcppThread", "R.utils", "RSQLite", "DBI", "rlang", "tibble", "fs", "PKNCA", "dplyr", "stringr", "ggplot2", "pracma")) The Simcyp R package is distributed from Simcyp support via a download link and can be requested from simcyp.support@certara.com.
Download the package archive file from the Simcyp download portal
Navigate to RStudio > Tools > Install Packages.
In the Install from: dropdown selection, change to Package archive file and select the Simcyp R package .zip file in your file explorer.
The current Released Version of the Simcyp R package is Simcyp_23.0.64.zip.
Install Simcyp VBE Shiny application
Type the command:
install.packages(
"Certara.SimcypVBE",
repos = c("https://certara.jfrog.io/artifactory/certara-cran-release-public/", "https://cloud.r-project.org"), method = "libcurl")